Nutrition policy papers and guidelines leave unstated the obvious fact that calcidiol and calcitriol are not nutrients, and that those metabolites are not pertinent to food fortification or dietary supplementation. Calcidol is the major circulating metabolite of cholecalciferol, while calcitriol is the hormone that upregulates the active transport of calcium from the gut, and which suppresses parathyroid hormone secretion.
In contrast, ergocalciferol is primarily a synthetic and less stable product which is less potent per microgram dose than is cholecalciferol. In nature, by far the major form of vitamin D that nurtures the body is cholecalciferol. The term “supplementation” has been used in the context of cholecalciferol, ergocalciferol, calcidiol, and calcitriol.
The specific compound that is meant for use in the context of vitamin D supplementation is often ambiguous.
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